Comparative structure activity and target exploration of 1,2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans

Infections and diseases caused by parasitic nematodes have a major adverse impact on the health and productivity of animals and humans worldwide. The control of these parasites often relies heavily on the treatment with commercially available chemical compounds (anthelmintics). However, the excessiv...

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Main Authors:	Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Nicholas Williamson, Bill C.H. Chang, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2024-08-01
Series:	International Journal for Parasitology: Drugs and Drug Resistance
Subjects:	Anthelmintic discovery Haemonchus contortus Caenorhabditis elegans Structure-activity relationship (SAR) Target identification Thermal proteome profiling
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211320724000150
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