ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer’s disease
Abstract In sporadic Alzheimer’s disease (sAD) specific regions, layers and neurons accumulate hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even in advanced disease. ApoER2-Dab1 signaling suppresses Tau phosphorylation as part of a four-arm pathway that regulate...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
BMC
2023-12-01
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| Saila: | Acta Neuropathologica Communications |
| Gaiak: | |
| Sarrera elektronikoa: | https://doi.org/10.1186/s40478-023-01693-9 |
| Etiketak: |
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