A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay

<p>Abstract</p> <p>Reliable quantitative evaluation of molecular pathways is critical for both drug discovery and treatment monitoring. We have modified the CAM assay to quantitatively measure vascular density, endothelial proliferation, and changes in protein expression in response to anti-angiogen...

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Autors principals:	Kohn Elise, Knezevic Vladimir, Lorang Dominique, Baibakov Galina, Vu Huan, He Mei, O'Connor Sarah, Patton Angela, Kayton Mark L, Miller Walter J, Alexander H Richard, Stirling David, Payvandi Faribourz, Muller George W, Libutti Steven K
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2004-01-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Angiogenesis Chorioallantoic membrane (CAM) Confocal microscopy XTT assay Layered Expression Scanning (LES)
Accés en línia:	http://www.translational-medicine.com/content/2/1/4
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