RNAi Screening Uncovers a Synthetic Sick Interaction between CtIP and the BARD1 Tumor Suppressor

Human CtIP is best known for its role in DNA end resection to initiate DNA double-strand break repair by homologous recombination. Recently, CtIP has also been shown to protect reversed replication forks from nucleolytic degradation upon DNA replication stress. However, still little is known about t...

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Bibliografski detalji

Glavni autori:	Hella A. Bolck, Sara Przetocka, Roger Meier, Christine von Aesch, Christina Zurfluh, Kay Hänggi, Vincent Spegg, Matthias Altmeyer, Michael Stebler, Simon F. Nørrelykke, Peter Horvath, Alessandro A. Sartori, Antonio Porro
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2022-02-01
Serija:	Cells
Teme:	CtIP BARD1 BRCA1 synthetic lethality replication stress DNA damage
Online pristup:	https://www.mdpi.com/2073-4409/11/4/643
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