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Phage cocktails containing a dual-receptor Phikzvirus suppress resistance evolution in Pseudomonas aeruginosa

ABSTRACT While phage therapy is one of the promising strategies against antimicrobial resistant infections by Pseudomonas aeruginosa, the rapid emergence of phage-resistant variants remains a significant barrier to its long-term clinical efficacy, reflecting the constant evolutionary arms race betwe...

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Principais autores: Jumpei Fujiki, Kohana Tamamura, Keisuke Nakamura, Tomohiro Nakamura, Yoshiaki Sakata, Nana Kimura, Sayaka Ono, Nozomi Kojima, Keiko Inaba-Hasegawa, Michihito Sasaki, Masaru Usui, Tomohito Iwasaki, Hiroki Ando, Hirofumi Sawa, Hidetomo Iwano
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-02-01
Serier:Applied and Environmental Microbiology
Fag:
phage therapy
phage cocktail
phage resistance
antimicrobial resistance (AMR)
fitness
trade-offs
Online adgang:https://journals.asm.org/doi/10.1128/aem.02095-25
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