Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase

Abstract Background Nonalcoholic steatohepatitis (NASH) is a progressive and inflammatory subtype of nonalcoholic fatty liver disease (NAFLD) characterized by hepatocellular injury, inflammation, and fibrosis in various stages. More than 20% of patients with NASH will progress to cirrhosis. Currentl...

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Autores principales:	Wei Shi, Guang Xu, Yuan Gao, Jun Zhao, Tingting Liu, Jia Zhao, Huijie Yang, Ziying Wei, Hui Li, An-Long Xu, Zhaofang Bai, Xiaohe Xiao
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2023-10-01
Colección:	Journal of Translational Medicine
Materias:	Epalrestat NASH Aldose reductase NLRP3 inflammasome NLRP3 inflammasome-driven disease
Acceso en línea:	https://doi.org/10.1186/s12967-023-04380-4
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