Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

Cardiac β-myosin variants cause hypertrophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation. The locations of variants on isolated myosin head structures predict contractility effects but not the prominent relaxation and energetic deficits that characterize...

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Autors principals:	Lorenzo Alamo, James S Ware, Antonio Pinto, Richard E Gillilan, Jonathan G Seidman, Christine E Seidman, Raúl Padrón
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2017-06-01
Col·lecció:	eLife
Matèries:	super-relaxation β-cardiac myosin diastolic heart disease cardiomyopathy myosin interacting-heads motif human mutation
Accés en línia:	https://elifesciences.org/articles/24634
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