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Agonistic anti-DCIR antibody inhibits ITAM-mediated inflammatory signaling and promotes immune resolution

DC inhibitory receptor (DCIR) is a C-type lectin receptor selectively expressed on myeloid cells, including monocytes, macrophages, DCs, and neutrophils. Its role in immune regulation has been implicated in murine models and human genome-wide association studies, suggesting defective DCIR function a...

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Hoofdauteurs: Liang Chen, Suresh Patil, Jeffrey Barbon, James Waire, Stephen Laroux, Donna McCarthy, Mishra Pratibha, Suju Zhong, Feng Dong, Karin Orsi, Gunarso Nguyen, Yingli Yang, Nancy Crosbie, Eric Dominguez, Arun Deora, Geertruida Veldman, Susan Westmoreland, Liang Jin, Timothy Radstake, Kevin White, Hsi-Ju Wei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical investigation 2024-06-01
Reeks:JCI Insight
Onderwerpen:
Autoimmunity
Immunology
Online toegang:https://doi.org/10.1172/jci.insight.176064
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