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Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19

Endothelial dysfunction accompanies the microvascular thrombosis commonly observed in severe COVID-19. Constitutively, the endothelial surface is anticoagulant, a property maintained at least in part via signaling through the Tie2 receptor. During inflammation, the Tie2 antagonist angiopoietin-2 (An...

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Principais autores: Alec A. Schmaier, Gabriel M. Pajares Hurtado, Zachary J. Manickas-Hill, Kelsey D. Sack, Siyu M. Chen, Victoria Bhambhani, Juweria Quadir, Anjali K. Nath, Ai-ris Y. Collier, Debby Ngo, Dan H. Barouch, Nathan I. Shapiro, Robert E. Gerszten, Xu G. Yu, MGH COVID-19 Collection and Processing Team, Kevin G. Peters, Robert Flaumenhaft, Samir M. Parikh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2021-10-01
coleção:JCI Insight
Assuntos:
COVID-19
Vascular biology
Acesso em linha:https://doi.org/10.1172/jci.insight.151527
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