Covalent modification of Keap1 Cys489 by NU6300 activates Nrf2 signaling and suppresses NLRP3 inflammasome-mediated pyroptosis

Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of oxidative stress and inflammasome, plays a critical role in modulating pyroptosis. In this study, we identified NU6300 as a novel small-molecule activator of Nrf2 that restores mitochondrial function, alleviates oxidative stre...

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Autores principales:	Xueqin Jiang, Hongyu Zheng, Xinlu Zhang, Minghai Tang, Jing Peng, Xiaoying Cai, Kaiyue Su, Ruijia Zhang, Neng Ye, Lei Lin, Rupei Ma, Caiyun Shen, Wenshuang Wu, Haoyu Ye
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-03-01
Colección:	Journal of Pharmaceutical Analysis
Materias:	Pyroptosis Keap1-Nrf2 NU6300 NLRP3 inflammasome Liver injury
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2095177925002758
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