The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that si...
में बचाया:
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Taylor & Francis Group
2021-05-01
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| श्रृंखला: | Molecular & Cellular Oncology |
| विषय: | |
| ऑनलाइन पहुंच: | http://dx.doi.org/10.1080/23723556.2021.1896349 |
| टैग: |
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