Region-specific mitophagy in nucleus pulposus, annulus fibrosus, and cartilage endplate of intervertebral disc degeneration: mechanisms and therapeutic strategies

Intervertebral disc degeneration (IVDD) is a prevalent condition contributing to various spinal disorders, posing a significant global health burden. Mitophagy plays a crucial role in maintaining mitochondrial quantity and quality and is closely associated with the onset and progression of IVDD. Wel...

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Main Authors: Chaoqun Feng, Ziang Hu, Min Zhao, Chuan Leng, Guangye Li, Fei Yang, Xiaohong Fan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2025-04-01
Sraith:Frontiers in Pharmacology
Ábhair:
mechanisms
therapeutic strategies
mitophagy
intervertebral disc degeneration
nucleus pulposus
annulus fibrosus
Rochtain Ar Líne:https://www.frontiersin.org/articles/10.3389/fphar.2025.1579507/full
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