Benzimidazoles Containing Piperazine Skeleton at C-2 Position as Promising Tubulin Modulators with Anthelmintic and Antineoplastic Activity

Benzimidazole anthelmintic drugs hold promise for repurposing as cancer treatments due to their interference with tubulin polymerization and depolymerization, manifesting anticancer properties. We explored the potential of benzimidazole compounds with a piperazine fragment at C-2 as tubulin-targetin...

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Principais autores:	Kameliya Anichina, Anelia Mavrova, Dimitar Vuchev, Galya Popova-Daskalova, Giada Bassi, Arianna Rossi, Monica Montesi, Silvia Panseri, Filip Fratev, Emilia Naydenova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-10-01
coleção:	Pharmaceuticals
Assuntos:	benzimidazole piperazine tubulin modulators anthelmintic activity antitumor activity LDH cellular release
Acesso em linha:	https://www.mdpi.com/1424-8247/16/11/1518
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