Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement and inflammation modulators

Abstract Urate-lowering treatment (ULT) to target with xanthine oxidase inhibitors (XOIs) paradoxically causes early increase in gouty arthritis flares. Because delayed reduction in flare burden is mechanistically unclear, we tested for ULT inflammation responsiveness markers. Unbiased proteomics an...

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Detalhes bibliográficos

Principais autores:	Concepcion Sanchez, Anaamika Campeau, Ru Liu-Bryan, Ted R. Mikuls, James R. O’Dell, David J. Gonzalez, Robert Terkeltaub
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-10-01
coleção:	Scientific Reports
Assuntos:	Xanthine oxidase Allopurinol Febuxostat Gout Inflammation Proteomics
Acesso em linha:	https://doi.org/10.1038/s41598-024-74154-5
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