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In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution

The role of clonal complexity has gradually been accepted in infection by Mycobacterium tuberculosis (MTB), although analyses of this issue are limited. We performed an in-depth study of a case of recurrent MTB infection by integrating genotyping, whole genome sequencing, analysis of gene expression...

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Principais autores: Darío García de Viedma, Yurena Navarro, Laura Pérez-Lago, Marta Herranz, Olalla Sierra, Iñaki Comas, Javier Sicilia, Emilio Bouza
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-04-01
coleção:Frontiers in Microbiology
Assuntos:
microevolution
Mycobacterium tuberculosis
functional analysis
in vitro infections
in vivo infections
whole genome sequencing
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00694/full
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