Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?

Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease hallmarked by irreversible damage of cartilage and bone. Matrix metalloproteinases (MMPs) involved in connective tissue remodeling play an important role in this process. Numerous MMPs have been examined in humans and anim...

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Autors principals:	Ádám Horváth, Bálint Botz, Tamás Kiss, Kata Csekő, Ibolya Kiss, Attila Felinger, Tamara Szabados, Éva Kenyeres, Péter Bencsik, Attila Mócsai, Péter Ferdinandy, Zsuzsanna Helyes
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2019-03-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	rheumatoid arthritis matrix metalloproteinases K/BxN serum-transfer arthritis subantimicrobial dose doxycycline bone homeostasis in vivo optical imaging
Accés en línia:	https://www.frontiersin.org/article/10.3389/fphar.2019.00233/full
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