Microphysiological Conditions Do Not Affect MDR1-Mediated Transport of Rhodamine 123 above an Artificial Proximal Tubule

Despite disadvantages, such as high cost and their poor predictive value, animal experiments are still the state of the art for pharmaceutical substance testing. One reason for this problem is the inability of standard cell culture methods to emulate the physiological environment necessary to recapi...

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Autors principals:	Negin Namazian Jam, Felix Gottlöber, Melanie Hempel, Yuliya Dzekhtsiarova, Stephan Behrens, Frank Sonntag, Jan Sradnick, Christian Hugo, Florian Schmieder
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-07-01
Col·lecció:	Biomedicines
Matèries:	proximal tubule multidrug resistance protein 1 (MDR1) transport kinetics tariquidar microphysiological systems rhodamine 123
Accés en línia:	https://www.mdpi.com/2227-9059/11/7/2045
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