Engineered miR-214 enriched Schwann cell-derived extracellular vesicles amplify therapeutic efficacy for peripheral neuropathy in T2D mice

Extracellular vesicles (EVs) derived from healthy Schwann cells (SC-EVs) ameliorate peripheral neuropathy in diabetic mice and rescue sciatic nerve function in Schwann cell Dicer knockout mice in part via SC-EV cargo miRNAs. Among these miRNAs, miR-214 repairs nerve damage. The present study investi...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Lei Wang, Xuerong Lu, Alexandra Szalad, Yi Zhang, Yanfeng Li, Mei Lu, Amy Kemper, Zhongwu Liu, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-08-01
Schriftenreihe:	Frontiers in Cellular Neuroscience
Schlagworte:	Schwann cells engineered extracellular vesicles microRNAs peripheral neuropathy diabetes mice
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1649830/full
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