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Dual epigenetic and nuclear export inhibition by chidamide and selinexor in high grade B-cell lymphomas via survivin and PI3K/AKT inhibition

Abstract Backgound High-grade B-cell lymphoma with concurrent MYC and BCL2/BCL6 rearrangements (HGBL-DHL) is a highly aggressive disease that is resistant to conventional first-line immunochemotherapeutic regimens. This resistance necessitates the exploration of innovative therapeutic strategies. Re...

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Principais autores: Jiazhen Lin, Xinguo Zhuang, Shuman Jia, Hui Zhou, Dongmei Qin, Jie Zhou, Bozhang Chen, Mingxin Zhuang, Bing Xu, Jie Zha
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
coleção:Clinical Epigenetics
Assuntos:
HGBL-DHL
Chidamide
Selinexor
Synergy
PI3K/AKT signaling
Survivin
Acesso em linha:https://doi.org/10.1186/s13148-026-02056-6
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