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A new mouse model of typhoid fever using Salmonella enterica serovar Paratyphi C as a surrogate pathogen

ABSTRACT Salmonella enterica serovar (S.) Typhi, the etiological agent of typhoid fever, is strictly human adapted, which presents a significant challenge for studying its pathogenesis in animal models. A common strategy to overcome this limitation is to infect mice with S. Typhimurium as a surrogat...

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Principais autores: Hoan T. Pham, Masatomo Morita, Kohei Yamazaki, Toshihiro Endo, Satoshi Takayama, Azusa Hiyoshi, Takeshi Haneda, Renée M. Tsolis, Andreas J. Bäumler, Toshio Kodama, Hirotaka Hiyoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-02-01
Serier:mBio
Fag:
Salmonella
typhoid
mouse model
Online adgang:https://journals.asm.org/doi/10.1128/mbio.03622-25
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