Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concern

Several families of viruses encode helicase enzymes with essential roles in viral genome replication and transcription, including several RNA virus families of pandemic concern, such as coronaviruses and flaviviruses. Viral helicases are widely considered to be promising antiviral targets with some...

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Hlavní autoři:	Nicole L. Inniss, Margarita Rzhetskaya, Ryan P. Kich, Elizabeth Gleason, Taha Y. Taha, Francisco J. Zapatero-Belinchón, Julia Rosecrans, Valentina Pedrero-Classen, Kenneth Huang, Gilles Degotte, Luca Lizzadro, Jason Pattie, Adam R. Renslo, George Minasov, Melanie Ott, Kelly E.R. Bachta, Karla J.F. Satchell, Judd F. Hultquist
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-08-01
Edice:	SLAS Discovery
Témata:	Drug repurposing SARS-CoV-2 nsp13 NS3 Helicase Antiviral drug discovery
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2472555226000171
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