Bromodomain Inhibitors Modulate FcγR-Mediated Mononuclear Phagocyte Activation and Chemotaxis

IgG antibodies form immune complexes (IC) that propagate inflammation and tissue damage in autoimmune diseases such as systemic lupus erythematosus. IgG IC engage Fcγ receptors (FcγR) on mononuclear phagocytes (MNP), leading to widespread changes in gene expression that mediate antibody effector fun...

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Prif Awduron:	Gemma D. Banham, Colin Y. C. Lee, John R. Ferdinand, Rebeccah J. Matthews, Chenzhi Jing, Nicholas Smithers, Rab K. Prinjha, Menna R. Clatworthy
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2022-05-01
Cyfres:	Frontiers in Immunology
Pynciau:	BET inhibitors systemic lupus erythematosus (SLE) Fcγ-receptor dendritic cell chemotaxis antibody-mediated inflammation
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.885101/full
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