Modifying nutritional substrates induces macrovesicular lipid droplet accumulation and metabolic alterations in a cellular model of hepatic steatosis

Abstract Background and Aims Nonalcoholic fatty liver disease (NAFLD) begins with steatosis, where a mixed macrovesicular pattern of large and small lipid droplets (LDs) develops. Since in vitro models recapitulating this are limited, the aims of this study were to develop mixed macrovesicular steat...

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Auteurs principaux:	Pippa J. Gunn, Camilla Pramfalk, Val Millar, Thomas Cornfield, Matthew Hutchinson, Elspeth M. Johnson, Shilpa R. Nagarajan, Perla Troncoso‐Rey, Richard F. Mithen, Katherine E. Pinnick, Maria H. Traka, Charlotte J. Green, Leanne Hodson
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2020-07-01
Collection:	Physiological Reports
Sujets:	fatty acid lipid droplet macrovesicular steatosis metabolism NAFLD RNA sequencing
Accès en ligne:	https://doi.org/10.14814/phy2.14482
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