Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for stage III melanoma: outcomes and the impact of the microbiome from the NeoACTIVATE trial

Background Neoadjuvant treatment has become standard for patients with high-risk operable stage III melanoma, but the optimal regimen is unknown. Targeted therapy approaches yield high pathological response rates, while immunotherapy regimens show favorable recurrence-free survival (RFS). NeoACTIVAT...

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Autors principals:	Jun Chen, Stephen Johnson, Haidong Dong, Evidio Domingo-Musibay, Matthew S Block, David Zahrieh, Lu Yang, Robert R McWilliams, Svetomir N Markovic, Tina J Hieken, Jane Yuet Ching Hui, Anastasios Dimou, Eric P Grewal, Courtney L Erskine, Garth D Nelson, Thomas James Flotte, Lisa A Kottschade, Heather N Montane, Mara A Piltin, Daniel L Price, Samir S Khariwala, Carrie A Strand
Format:	Artigo
Idioma:	Inglês
Publicat:	BMJ Publishing Group 2025-04-01
Col·lecció:	Journal for ImmunoTherapy of Cancer
Accés en línia:	https://jitc.bmj.com/content/13/4/e011706.full
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