Decoding the structural basis of ligand recognition and biased signaling in the motilin receptor

Summary: The motilin receptor (MTLR) is a key target for treating gastrointestinal (GI) disorders like gastroparesis, yet developing effective agonists remains challenging due to drug tolerance and signaling bias. We present cryoelectron microscopy (cryo-EM) structures of MTLR bound to azithromycin,...

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Autori principali:	Chongzhao You, Mengting Jiang, Tianyu Gao, Zining Zhu, Xinheng He, Youwei Xu, Yuan Gao, Yi Jiang, H. Eric Xu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-03-01
Serie:	Cell Reports
Soggetti:	CP: Molecular biology
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124725001007
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