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A Lysine Residue at the C-Terminus of MHC Class I Ligands Correlates with Low C-Terminal Proteasomal Cleavage Probability

The majority of peptides presented by MHC class I result from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases can, either alone or together with the proteasome,...

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Principais autores: Adrian Schmalen, Ilona E. Kammerl, Silke Meiners, Elfriede Noessner, Cornelia A. Deeg, Stefanie M. Hauck
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-08-01
Serier:Biomolecules
Fag:
immunopeptidomics
proteasome independent
non-canonical MHC class I ligands
HLA-A*03:01
HLA-A*11:01
HLA-A*30:01
Online adgang:https://www.mdpi.com/2218-273X/13/9/1300
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