Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration

Acute skeletal muscle injury triggers an expansion of fibro/adipogenic progenitors (FAPs) and a transient stage of fibrogenesis characterized by extracellular matrix deposition. While the perpetuation of such phase can lead to permanent tissue scarring, the consequences of its suppression remain to...

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Hlavní autoři:	Daniela Fiore, Robert N. Judson, Marcela Low, Sunny Lee, Erica Zhang, Claudia Hopkins, Peter Xu, Andrea Lenzi, Fabio M.V. Rossi, Dario R. Lemos
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2016-07-01
Edice:	Stem Cell Research
Témata:	Fibro/adipogenic progenitors Satellite cells Fibrosis Myogenesis Regeneration Protein-tyrosine kinase inhibitors
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1873506116300708
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