TNF-α knockout and minocycline treatment attenuates blood–brain barrier leakage in MPTP-treated mice

Following intraparenchymal injection of the dopamine (DA) neurotoxin 6-hydroxydopamine, we previously demonstrated passage of fluoresceinisothiocyanate-labeled albumin (FITC-LA) from blood into the substantia nigra (SN) and striatum suggesting damage to the blood–brain barrier (BBB). The factors con...

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Dades bibliogràfiques

Autors principals:	Chaohui Zhao, Zaodung Ling, Mary B. Newman, Ankush Bhatia, Paul M. Carvey
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2007-04-01
Col·lecció:	Neurobiology of Disease
Matèries:	Parkinson’s disease Neuroinflammation Microglia TNF-α IL-1β Minocycline
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S096999610600307X
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