Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration

Abstract Background Extracellular matrix stiffness is emerging as a crucial mechanical cue that drives the progression of various diseases, such as cancer, fibrosis, and inflammation. The matrix stiffness of the nucleus pulposus (NP) tissues increase gradually during intervertebral disc degeneration...

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Auteurs principaux:	Wencan Ke, Bingjin Wang, Zhiwei Liao, Yu Song, Gaocai Li, Liang Ma, Kun Wang, Shuai Li, Wenbin Hua, Cao Yang
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2023-10-01
Collection:	Journal of Translational Medicine
Sujets:	Matrix stiffness Mechanotransduction Mitochondrial fission Piezo1 Nucleus pulposus Intervertebral disc degeneration
Accès en ligne:	https://doi.org/10.1186/s12967-023-04590-w
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