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Chronic intermittent hypoxia exacerbates isoproterenol-induced cardiac hypertrophy and apoptosis

BackgroundObstructive sleep apnea (OSA) is marked by chronic intermittent hypoxia (CIH) and iassociated with multiple cardiovascular complications. Isoproterenol (ISO) is commonly used to induce cardiac hypertrophy. However, the impact of CIH on ISO-induced cardiac hypertrophy and remodeling remains...

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Principais autores: Yujie Zhang, Ming Zhang, Hongfeng Jiang, Fang Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Cardiovascular Medicine
Assuntos:
chronic intermittent hypoxia
isoproterenol
cardiomyocyte hypertrophy
cardiac remodeling
apoptosis
PI3K/Akt/mTOR pathway
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1700967/full
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