Mass spectrometry methods and mathematical PK/PD model for decision tree-guided covalent drug development

Abstract Covalent drug discovery efforts are growing rapidly but have major unaddressed limitations. These include high false positive rates during hit-to-lead identification; the inherent uncoupling of covalent drug concentration and effect [i.e., uncoupling of pharmacokinetics (PK) and pharmacodyn...

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主要な著者:	Md Amin Hossain, Rutali R. Brahme, Brandon C. Miller, Jakal Amin, Marcela de Barros, Jaime L. Schneider, Jared R. Auclair, Carla Mattos, Qingping Wang, Nathalie Y. R. Agar, David J. Greenblatt, Roman Manetsch, Jeffrey N. Agar
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-02-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-025-56985-6
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