Effect of methotrexate/dexamethasone combination on epithelial-mesenchymal transition and inflammation gene expression of human RPE cells in-vitro

IntroductionRPE cells serve as an experimental model for studying a retinal disease called proliferative vitreoretinopathy (PVR). The pathological background of PVR involves uncontrolled cell proliferation, increased inflammation, and enhanced epithelial-mesenchymal transition (EMT), which have been...

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Autori principali:	Fatemeh Sanie-Jahromi, Mahdi Ravankhah, Hossein Shafi Khani, Seyed Ahmad Razavizadegan, M. Hossein Nowroozzadeh
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-04-01
Serie:	Frontiers in Pharmacology
Soggetti:	methotrexate dexamethasone apoptosis inflammation EMT RPE
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1569703/full
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