Half-dose glucarpidase: an effective rescue for toxic methotrexate plasma concentrations in a patient with bilateral primary vitreoretinal lymphoma

Abstract Primary vitreoretinal lymphoma (PVRL) is a rare, aggressive subtype of central nervous system lymphoma that initially presents in the eye. High-dose methotrexate (HD-MTX) is a key component of systemic therapy, but its use can be complicated by nephrotoxicity and delayed drug clearance, req...

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Principais autores:	Ángela González-Román, Thais Lizondo, Carla Bastida, Inés Monge-Escartín, Gisela Riu, Esther Carcelero, Eduardo Aguilar, Anna Gaya, Dolors Soy
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer 2026-04-01
Serija:	Annals of Hematology
Teme:	Glucarpidase Methotrexate plasma concentration Acute kidney injury Folinic acid
Online dostop:	https://doi.org/10.1007/s00277-026-06943-z
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