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Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity

Abstract Background Redox imbalance and inflammation have been proposed as the principal mechanisms of damage in the auditory system, resulting in functional alterations and hearing loss. Microglia and astrocytes play a crucial role in mediating oxidative/inflammatory injury in the central nervous s...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Fabiola Paciello, Anna Pisani, Rolando Rolesi, Raffaele Montuoro, Veronica Mohamed-Hizam, Giammarco Boni, Cristian Ripoli, Jacopo Galli, Renata Sisto, Anna Rita Fetoni, Claudio Grassi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2024-01-01
Schriftenreihe:Journal of Neuroinflammation
Schlagworte:
ROS
Pro-inflammatory cytokines
Macrophages
Microglia morphology
Astrogliosis
Gap junctions
Online-Zugang:https://doi.org/10.1186/s12974-023-02996-3
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