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Ribonucleotide reductase, a novel drug target for gonorrhea

Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum of activity against Ng including MDR isolates....

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Auteurs principaux: Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications Ltd 2022-02-01
Collection:eLife
Sujets:
neisseria gonorrhoeae
gonorrhea
ribonucleotide reductase
multidrug resistance
2-pyridone
Accès en ligne:https://elifesciences.org/articles/67447
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