Harnessing natural terpenes via PEGylated mucoadhesive vesicles for improved urinary bladder delivery: from in vitro evaluation to in vivo assessment

BackgroundFenticonazole nitrate (FTN)-loaded chitosan-coated PEGylated terpesomes (TPs) were investigated as a mucoadhesive formulation to enhance drug delivery to the urinary bladder.MethodsThe design of fenticonazole nitrate-loaded terpesome (FTN-TP) formulations was carried out using a 31.21 fact...

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Principais autores:	Hayder A. Hammoodi, Rofida Albash, Mohammed I. A. Hamed, Khaled M. Darwish, Amira B. Kassem, Asmaa Saleh, Jawaher Abdullah Alamoudi, Noha M. Badawi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-12-01
coleção:	Frontiers in Pharmacology
Assuntos:	intravesical delivery fenticonazole nitrate terpesomes chitosan gelucire confocal laser scanning microscopy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1685423/full
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