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Integrating transcriptomics and scPagwas analysis predicts naïve CD4 T cell-related gene DRAM2 as a potential biomarker and therapeutic target for colorectal cancer

Abstract Objective The interaction between T cells, particularly naïve CD4 T cells (CD4Tn), and colorectal cancer (CRC) is highly complex. CD4Tn play a crucial role in modulating immune responses within the tumor microenvironment, yet the precise mechanisms by which they influence tumor progression...

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Principais autores: Rui Feng, Xiaofang Li, Benhua Li, Tiankuo Luan, Jiaming He, Guojing Liu, Jian Yue
格式: Artigo
語言:Inglês
出版: BMC 2025-02-01
叢編:BMC Cancer
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在線閱讀:https://doi.org/10.1186/s12885-025-13731-x
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