Discovery of novel proteasome inhibitors using a high-content cell-based screening system.
The regulated degradation of damaged or misfolded proteins, as well as down-regulation of key signaling proteins, within eukaryotic and bacterial cells is catalyzed primarily by large, ATP-dependent multimeric proteolytic complexes, termed proteasomes. Inhibition of proteasomal activity affects a wi...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science (PLoS)
2009-12-01
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| Sarja: | PLoS ONE |
| Linkit: | https://doi.org/10.1371/journal.pone.0008503 |
| Tagit: |
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