Long noncoding RNA RP11-241J12.3 targeting pyruvate carboxylase promotes hepatocellular carcinoma aggressiveness by disrupting pyruvate metabolism and the DNA mismatch repair system

Abstract Accumulating evidence indicates that hepatitis B virus X protein (HBx) plays a key role in HBV-related hepatocellular carcinoma (HCC) aggressiveness; however, the underlying mechanisms are not entirely clear. Long non-coding RNAs (lncRNAs), which participate in the regulation of diverse bio...

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Autori principali:	Liuliu Cheng, Shichuan Hu, Jinhu Ma, Yongheng Shu, Yanwei Chen, Bin Zhang, Zhongbing Qi, Yunmeng Wang, Yan Zhang, Yuwei Zhang, Ping Cheng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2022-02-01
Serie:	Molecular Biomedicine
Soggetti:	Hepatocellular carcinoma HBx LncRNAs RP11-241J12.3 DNA MMR Pyruvate metabolism
Accesso online:	https://doi.org/10.1186/s43556-021-00065-w
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