Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response

During infections with protozoan parasites or some viruses, T cell immunosuppression is generated simultaneously with a high B cell activation. It has been described that, as well as producing antibodies, plasmablasts, the differentiation product of activated B cells, can condition the development o...

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Principais autores:	Melisa Gorosito Serrán, Facundo Fiocca Vernengo, Laura Almada, Cristian G. Beccaria, Yamila Gazzoni, Pablo F. Canete, Jonathan A. Roco, Jimena Tosello Boari, Maria Cecilia Ramello, Ellen Wehrens, Yeping Cai, Elina I. Zuniga, Carolina L. Montes, Ian A. Cockburn, Eva V. Acosta Rodriguez, Carola G. Vinuesa, Adriana Gruppi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-05-01
coleção:	Frontiers in Immunology
Assuntos:	plasmablasts/plasma cells B cell PD-L1 Trypanosoma cruzi Plasmodium LCMV
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.828734/full
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