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Super enhancer related gene ANP32B promotes the proliferation of acute myeloid leukemia by enhancing MYC through histone acetylation

Abstract Background Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system, and childhood AML accounts for about 20% of pediatric leukemia. ANP32B, an important nuclear protein associated with proliferation, has been found to regulate hematopoiesis and CML leukemogenesis by inhibit...

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Principais autores: Xiaomei Wan, Jianwei Wang, Fang Fang, Yixin Hu, Zimu Zhang, Yanfang Tao, Yongping Zhang, Juanjuan Yu, Yumeng Wu, Bi Zhou, Hongli Yin, Li Ma, Xiaolu Li, Ran Zhuo, Wei Cheng, Shuqi Zhang, Jian Pan, Jun Lu, Shaoyan Hu
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-02-01
Series:Cancer Cell International
Assuntos:
Acute myeloid leukemia
ANP32B
C-MYC
Histone Acetylation
H3K27ac
Acceso en liña:https://doi.org/10.1186/s12935-024-03271-y
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