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Synthesis and Preliminary Evaluation of a Novel 18F-Labeled 2-Nitroimidazole Derivative for Hypoxia Imaging

ObjectiveHypoxia is prevalent in tumors and plays a pivotal role in resistance to chemoradiotherapy. 18F-MISO (18F-labeled fluoromisonidazole) is currently the preferred choice of PET hypoxia tracers in clinical practice, but has severe disadvantages involving complex labeling methods and low effici...

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Principais autores: Jing Lu, Chi Zhang, Xi Yang, Xi-Juan Yao, Qun Zhang, Xin-Chen Sun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-02-01
coleção:Frontiers in Oncology
Assuntos:
PET tracer
hypoxia
2-nitroimidazole
chemoradiotherapy resistance
18F
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2020.572097/full
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