Low Shear Stress Promotes Atherosclerosis by Mediating Pathological Accumulation of Endothelial Lipid Droplets via the KLF4/TFEB/ATP1A1 Axis

Background: Atherosclerosis preferentially develops at arterial regions exposed to low shear stress (LSS), highlighting the critical role of local hemodynamic forces in disease initiation and progression. Emerging evidence indicates that endothelial lipid metabolism is a key determinant of vascular...

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主要な著者:	Yi Shi, Ya-Nan Tan, Li-Da Wu, Li-Guo Wang, Yue Gu, Wen-Ying Zhou, Meng-Qian Shao, Jun-Xia Zhang
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2026-05-01
シリーズ:	Journal of Cardiovascular Development and Disease
主題:	low shear stress lipid droplets atherosclerosis lipophagy KLF4
オンライン･アクセス:	https://www.mdpi.com/2308-3425/13/5/213
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