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Synergistic Effect of Bypassing Agents and Sequence Identical Analogue of Emicizumab and Fibrin Clot Structure in the In Vitro Model of Hemophilia A

Development of inhibitors to factor VIII (FVIII) occurs in approximately 30% of severe hemophilia A (HA) patients. These patients are treated with bypassing agents (activated prothrombin complex concentrate [aPCC] and recombinant activated FVII-rFVIIa). Recently, a bispecific FIX/FIXa- and FX/FXa-di...

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Principais autores: Yanan Zong, Aleksandra Antovic, Nida Mahmoud Hourani Soutari, Jovan Antovic, Iva Pruner
Formato: Artigo
Idioma:Inglês
Publicado em: Georg Thieme Verlag KG 2020-04-01
coleção:TH Open
Assuntos:
emicizumab
bypassing agents
fibrin clot
hemophilia a
Acesso em linha:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1710032
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