βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors

Abstract Background WNT/βcatenin (WNTβ) pathway is activated in early stages of embryonic development. We aimed to evaluate the significance of βcatenin in germ cell tumors (GCTs) and explore associations with the inflamed environment. Methods Surgical specimens from 247 patients were analyzed. Βcat...

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Detalhes bibliográficos

Principais autores:	Michal Chovanec, Zuzana Cierna, Viera Miskovska, Katarina Machalekova, Katarina Kalavska, Katarina Rejlekova, Daniela Svetlovska, Dusan Macak, Stanislav Spanik, Karol Kajo, Pavel Babal, Michal Mego, Jozef Mardiak
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-11-01
coleção:	BMC Cancer
Assuntos:	βcatenin WNTβ pathway PD-L1 Systemic-immune inflammation Tumor infiltrating lymphocytes
Acesso em linha:	http://link.springer.com/article/10.1186/s12885-018-4929-x
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