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Rescuing the bacterial replisome at a nick requires recombinational repair and helicase reloading

Abstract DNA damage occurs in all cells and must be repaired to maintain genome integrity. Many DNA lesions are targeted for removal by repair systems that excise the damage, thereby generating a temporary single-strand discontinuity in the chromosome. If DNA repair has not been completed prior to a...

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Autors principals: Charles Winterhalter, Kathryn J. Stratton, Stepan Fenyk, Heath Murray
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2025-11-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-025-66550-w
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