Binding modes of prothrombin cleavage site sequences to the factor Xa catalytic triad: Insights from atomistic simulations
Prothrombin is a key zymogen of the coagulation process and can be converted to thrombin by the prothrombinase complex, which consists of factor Xa (FXa), cofactor Va (FVa), and phospholipids. Prothrombin can be activated at two cleavage sites, R271 and R320, which generates two intermediates: preth...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Association for the Advancement of Science (AAAS)
2022-01-01
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| Col·lecció: | Computational and Structural Biotechnology Journal |
| Matèries: | |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S2001037022004354 |
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