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Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host

Cerebral malaria (CM) is a clinical syndrome involving irreversible and lethal signs of brain injury associated to infection by parasites of the genus Plasmodium. The pathogenesis of CM derives from infection-induced proinflammatory cytokines associated with cytoadherence of parasitized red blood ce...

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Principais autores: Pollyanna Stephanie Gomes, Scott Tanghe, Julio Gallego-Delgado, Luciana Conde, Leonardo Freire-de-Lima, Ana Carolina Lima, Célio Geraldo Freire-de-Lima, Josué da Costa Lima Junior, Otacílio Moreira, Paulo Totino, Ana Rodriguez, Adriane Regina Todeschini, Alexandre Morrot
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-02-01
coleção:Frontiers in Microbiology
Assuntos:
Plasmodium falciparum
glycobyology
cerebral malaria
treatment strategies
parasites
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2019.00305/full
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