Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses

Abstract Background Metagenomics is a powerful approach for the detection of unknown and novel pathogens. Workflows based on Illumina short-read sequencing are becoming established in diagnostic laboratories. However, high sequencing depth requirements, long turnaround times, and limited sensitivity...

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Autori principali:	Sarah Buddle, Leysa Forrest, Naomi Akinsuyi, Luz Marina Martin Bernal, Tony Brooks, Cristina Venturini, Charles Miller, Julianne R. Brown, Nathaniel Storey, Laura Atkinson, Timothy Best, Sunando Roy, Sian Goldsworthy, Sergi Castellano, Peter Simmonds, Heli Harvala, Tanya Golubchik, Rachel Williams, Judith Breuer, Sofia Morfopoulou, Oscar Enrique Torres Montaguth
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-09-01
Serie:	Genome Medicine
Soggetti:	Clinical metagenomics Viral diagnostics Pathogen detection Epidemiological surveillance Next-generation sequencing
Accesso online:	https://doi.org/10.1186/s13073-024-01380-x
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