Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-mediated pyroptosis in intestinal epithelial cells

Abstract Introduction Radiation-induced intestinal injury (IR) is a common complication in patients with colorectal cancer (CRC) after radiotherapy. Currently, the search for effective treatments has become an urgent priority. Nicotinamide riboside (NR), the precursor of vitamin B3 derivative and NA...

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Main Authors: Qian Zhou, Le Liu, Xinlong Lin, Binhai Shen, Weifeng Huang, Yin Zhang, Yinmu Li, Yuyi Yang, Hongbin Liu, Wendi Zhang, Xinmei Zhao, Weiguang Qiao, Yangyang Liu, Gao Tan, Fachao Zhi
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMC 2025-10-01
Sraith:Journal of Translational Medicine
Ábhair:
Radiation-induced intestinal injury
Nicotinamide riboside
Gasdermin E
Pyroptosis
Intestinal epithelial cells
Rochtain Ar Líne:https://doi.org/10.1186/s12967-025-07012-1
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